Polyethylene glycol di(beta-4-[4-(2-dimethylamino-2-benzyl)butaonylphenyl]piperazine)propionate - Names and Identifiers
Polyethylene glycol di(beta-4-[4-(2-dimethylamino-2-benzyl)butaonylphenyl]piperazine)propionate - Physico-chemical Properties
Polyethylene glycol di(beta-4-[4-(2-dimethylamino-2-benzyl)butaonylphenyl]piperazine)propionate - Introduction
Polyethylene Glycol di (β-4[ 4-(2-dimethylamino-2-benzyl) butaonylphenyl] piperazine ) propionate, also abbreviated as PEG-(4-DAB) 2 P. The following is a description of the properties, uses, preparation and safety information of this polymer:
Nature:
-Appearance: White or nearly white powder.
-Solubility: Soluble in many organic solvents, such as chloroform, methanol and dimethyl sulfoxide.
-Melting point: about 110-130 ℃.
-Molecular structure: The polymer has multiple polyethylene glycol chains and Piperazine rings, which are connected by 4-DAB(4-(2-dimethylamino-2-benzyl) butanone phenyl) in the middle.
Use:
-Drug delivery system: PEG-(4-DAB) 2 P can be used as a carrier of drug delivery system, which can effectively enhance the solubility, stability and bioavailability of drugs, while reducing the side effects of drugs.
-Cosmetics: Surfactants and thickeners used in skin care products and make-up.
-Chemical synthesis catalyst: exists as a reducing agent or catalyst.
Preparation Method:
The preparation of Polyethylene Glycol di (β-4[ 4-(2-dimethylamino-2-benzyl) butaonylphenyl] piperazine ) propionate usually involves the following steps:
1. reacting polyethylene glycol with 4-DAB in dichloromethane to generate PEG-(4-DAB) conjugate.
2. Reaction of PEG-(4-DAB) with Piperazine in dimethyl carbonate to produce PEG-(4-DAB) 2 P product.
3. the product is purified by extraction, crystallization and other processes.
Safety Information:
-may have a certain degree of irritation and sensitization, it is recommended to wear appropriate protective measures.
-Avoid contact with skin, eyes and mucous membranes, and avoid inhaling dust.
-Store and handle properly, away from ignition and oxidizing agents.
-Please follow the relevant safety procedures and recommendations when using.
Please note that the above information is for reference only, and relevant regulations and operating guidelines should be followed in practical applications.
Last Update:2024-04-09 15:18:00